Omeprazole before endoscopy in GI bleeds

PPIGIBleed

http://www.nejm.org/doi/full/10.1056/NEJMoa065703

Week 3.

• Conclusions
o In pt with bleeding peptic ulcers, improvements in clinical outcomes appreciated with those who received pretreatment with omeprazole prior to endscopy
o Optimal acid suppression with omeprazole aids in clot formation showing
• Fewer actively bleeding ulcers were seen on endoscopy
• Reduction in the need for endoscopic treatment
• Accelerates signs of bleeding resolution (ulcers with clean bases)- allowing for early discharge
o Omeprazole proves to stabilize clots, prevent recurrent bleeding, initiate healing

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